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. 2019 Nov 27;222(7):1108–1116. doi: 10.1093/infdis/jiz631

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© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — In vitro replication measurement of lamivudine-resistant subtype C clinical isolate containing M184V and L74I and revertant mutations. (A) Amino acid multiple sequence alignment of clinical isolate and revertant mutants generated by site-directed mutagenesis. Numbering is relative to strain HXB2. (B) In vitro reverse-transcription (RT) efficiency contained in pelleted single-round virus from cells producing clinical human immunodeficiency virus (HIV) isolate RT sequence and mutants. Bottom panel shows Western blot of corresponding virus-associated p24 in supernatants from cells. (C) Single-round infection of target HEK 293T cells by equal quantities of luciferase expressing vesicular stomatitis virus-G pseudotyped HIV viruses from B. Data in B and C were performed in replicate, and means are presented with error bars corresponding to standard deviation. RLU, relative light units.