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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Semin Pediatr Surg. 2020 Jul 23;29(4):150945. doi: 10.1016/j.sempedsurg.2020.150945

Table 4.

Histological Features of Specific Causes of Neonatal Cholestasis

Disorder Histology
Biliary obstruction Portal tract bile duct plugs, ductular reaction, portal tract fibrosis
A1AT deficiency Periodic acid Schiff-positive, diastase-resistant hepatocyte globules
Alagille syndrome Bile duct paucity
Neonatal sclerosing cholangitis Necro-inflammatory bile duct lesions
Inborn Errors of Metabolism Hepatic steatosis and pseudo-acinar formation of hepatocytes
PFIC types 1, 2 Electron microscopy - abnormal canalicular bile
Storage diseases Electron microscopy - lysosomal storage material
Transient Neonatal Cholestasis Multinucleated giant cells, extramedullary hematopoiesis, and hepatocellular cholestasis without portal tract involvement
Viral infections CMV inclusions and HSV, CMV on immunohistochemistry