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. 2020 Aug 25;9(2):5–18. doi: 10.5501/wjv.v9.i2.5

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Morphologically spherical but geometrically polyhedral formations. A: The virion-like universally adopted structures in human art and culture: 1. Ancient wood carving, Ephesus, Turkey; 2. Ancient Roman dodecahedron, Gallo-Roman Museum of Tongeren, Belgium; 3. Ancient petroglyph, Osirian Temple, Abydos, Egypt; 4. Neolithic stone spheres, Scotland, United Kingdom; 5. Guardian lion or Shishi, Yonghe Temple, Beijing, China; 6. Amazon Sphere, Seattle, United States; and 7. Tianjin Binhai Library, Tianjin, China; B: Spherical viruses with icosahedral capsids. PAV: Parvovirus; CMV: Cytomegalovirus; NV: Norovirus; HBV: Hepatitis B virus; 29¹: bacteriophage; SARS-CoV-2: Severe acute respiratory syndrome virus-2; BTV: Bluetongue virus; SV40: Simian virus 40; HSV-1: Herpes simplex virus; MLV: Murine leukemia virus; HIV-1: Human immunodeficiency virus-1; Influenza: Influenza virus.