Features and properties of remdesivir

Alternative names	Captisol-enabled remdesivir; Captisol®-enabled GS 5734; GS-5734; Veklury
Class	Adenine nucleotides; amines; antivirals; esters; furans; nitriles; phosphorus compounds; pyridazines; pyrroles; small molecules; triazines
Mechanism of action	RNA replicase inhibitors
Route of administration	Intravenous
Pharmacodynamics	Potent and dose-dependent antiviral activity against SARS-CoV-2; therapeutic effects in animal models of SARS-CoV-2
Pharmacokinetics	Undergoes metabolic activation to intracellularly form a pharmacologically active nucleoside analogue triphosphate; predominant circulating metabolite (GS-441524) eliminated via renal clearance
Most frequent adverse reactions
Very common (≥ 1/10)	Transaminases increased
Common (≥ 1/100 to < 1/10)	Nausea; headache; rash
ATC codes
WHO ATC code	J05A-X (other antivirals)
EphMRA ATC code	J5B9 (antivirals, others)
Chemical name	2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-b]pyridazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate