Table 2.

Univariate and multivariate Cox models for time to negativity

	Univariate model			Multivariate modela
	HR	95% CI	p value	HR	95% CI	p value
Age	1.04	0.99–1.09	0.14	1.05	0.995–1.12	0.071
Sex, female	1.78	0.81–3.93	0.15	1.35	0.58–3.12	0.490
Comorbidities	0.64	0.27–1.53	0.32
Cardiovascular disease	0.85	0.4–1.82	0.68
Type 2 diabetes mellitus	0.41	0.17–0.97	0.04	0.313	0.11–0.89	0.029
Hypertension	1.23	0.59–2.56	0.58
BMI	1.03	0.97–1.09	0.38
Chronic respiratory failure	0.69	0.25–1.86	0.46
Chronic renal failure	0.42	0.06–3.11	0.40
Solid or hematologic neoplasia	2.08	0.62–6.99	0.24
Lymphopenia duration	0.98	0.94–1.01	0.23
SAPS II at ICU admission	1.01	0.99–1.03	0.42
ARDS, severe	0.59	0.25–1.39	0.23
Thrombosis during ICU stay	1.33	0.64–2.77	0.44
AKI during ICU stay	0.60	0.29–1.25	0.17	1.09	0.48–2.52	0.84
VAP during ICU stay	0.80	0.38–1.66	0.54
UTI during ICU stay	1.10	0.47–2.59	0.82
Colitis during ICU stay	2.56	0.33–19.6	0.37
Corticosteroids during ICU stay	1.10	0.54–2.24	0.80
Antivirals	0.63	0.30–1.33	0.23
Tocilizumab	1.40	0.41–4.72	0.59

The proportionality hazard was assessed using Martingale residuals and was respected for diabetes mellitus (p = 0.38)

HR hazard ratio, CI confidence interval, BMI body mass index, SAPS Simplified Acute Physiology Score, ICU intensive care unit, VAP ventilator-associated pneumonia, UTI urinary tract infection, AKI acute kidney insufficiency

^aVariables included in the multivariate analysis were age, sex, type 2 diabetes mellitus, and AKI during ICU stay