TABLE 2.

MOF functional roles in different aspects of the DNA damage response, embryonic stem cell development, cellular death, and H4K16 acetylation

Biological function	Function(s) of MOF	Reference(s)
Regulation of gene expression by H4K16ac	Regulation of gene functions by influencing opening of chromatin	9, 14
	MOF is essential for oncogenesis and embryogenesis	18
DNA damage response	Interacts with and impacts ATM autophosphorylation at Ser1981	28
	Required for optimal functioning of NHEJ and HR pathways	29
	MOF phosphorylation at T392 site by ATM regulates DNA DSB pathway choice	31
	Reduced MOF levels correlate with reduced replication fork speed	32
Cellular death	p53 lysine 120 modification influences activation of proapoptotic genes	19
	MOF depletion leads to downregulation of autophagy	37
	MOF depletion results in death of Purkinje cells, leading to neurological abnormality	34
Stem cell development	Regulation of embryonic stem cell core transcriptional network	44
	MOF is associated with differentiation of iPSCs	46
	MOF is required for hematopoietic stem cell maintenance	51