Table 3.
Research topics | Research questions |
---|---|
Statin responsiveness | What are the effects of genetic and racial variation response of LDL cholesterol to different statins? |
Children and adolescents | What is the long-term ASCVD benefit or legacy effect of early statin therapy in children and adolescents? |
Safety in pregnancy | What is the safety of statins and their effect on fetal development? |
Statin intolerance | What are the mechanisms of type and dose effect of statins on the development of SAMS? |
Adherence | What are the concerns and beliefs of patients about statin use, and how could decision aids improve health literacy and the quality of decision-making process? |
Lipoprotein(a) | What are the mechanisms of statins on synthesis and clearance of Lp(a) particles? |
Coronary artery calcium score | What are the mechanisms of statins on arterial calcification and the progression of plaque volume? |
Statin-related therapies | What are the mechanisms of small interfering RNA (siRNA) therapies that inhibit HMG-CoA reductase on LDL metabolism? |