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. 2020 Sep 1;22(11):64. doi: 10.1007/s11883-020-00884-2

Table 3.

Suggestions for further research on statins, with implications for the management of familial hypercholesterolemia

Research topics Research questions
Statin responsiveness What are the effects of genetic and racial variation response of LDL cholesterol to different statins?
Children and adolescents What is the long-term ASCVD benefit or legacy effect of early statin therapy in children and adolescents?
Safety in pregnancy What is the safety of statins and their effect on fetal development?
Statin intolerance What are the mechanisms of type and dose effect of statins on the development of SAMS?
Adherence What are the concerns and beliefs of patients about statin use, and how could decision aids improve health literacy and the quality of decision-making process?
Lipoprotein(a) What are the mechanisms of statins on synthesis and clearance of Lp(a) particles?
Coronary artery calcium score What are the mechanisms of statins on arterial calcification and the progression of plaque volume?
Statin-related therapies What are the mechanisms of small interfering RNA (siRNA) therapies that inhibit HMG-CoA reductase on LDL metabolism?