Figure 4.
Effects of LIPUS on the renal injury in an acute kidney injury (AKI) mouse model of unilateral ischemia/reperfusion injury (IRI) with contralateral nephrectomy. Animals were euthanized 48 h after IRI. The LIPUS treatment was performed before IRI procedure and after IRI until the day of euthanization. (A) The serum blood urea nitrogen (BUN, a), creatinine (b), and cystatin C (CYS C, c) levels were shown. (B) Renal tissues were stained with Periodic Acid-Schiff (PAS) and pathological changes were observed under light microscope. Histological score was also recorded. Data are presented as mean ± SEM (n = 8). *p < 0.05 versus sham; # p < 0.05 versus IRI alone. Scale bar: 50 μm.