Table 1.

The candidate midgut proteins that interacted with P. falciparum.

Idx	ID	AA	Folds	Common name	Biological function	Category
F3	006,400	525	4	Alkaline phosphatase 2	Alkaline phosphatase activity	Digestion
B2	006,425	505	14.1	Cyanogenic beta-glucosidase	Carbohydrate metabolic process	Digestion
C5	013,078	414	10.6	Plasma glutamate carboxypeptidase	Peptide catabolic process, proteolysis	Digestion
D8	003,926	876	5	Aminopeptidase		Digestion
B5	004,900	259	13.4	Trypsin type 4	Serine-type peptidase activity	Digestion
A5	008,176	754	9	Dipeptidyl-peptidase 4		Digestion
A4	005,686	297	7.3	Eupolytin		Digestion
C4	001,245	272	8.3	Eupolytin		Digestion
H4	011,920	255	10.6	Eupolytin		Digestion
H5	005,795	3,499	12.5	Sodium-coupled monocarboxylate transporter 1	Transmembrane transporter activity	Digestion
C3	003,573	814	9.5	Uncharacterized	Bactericidal permeability-increasing protein	Protection
D1	006,268	94	6.1	Peritrophin	Chitin metabolic process	Protection
B8	002,851	151	4.2	Niemann-Pick Type C-2	Intracellular cholesterol transport, innate immunity	Protection
C2	007,197	483	5.4	Niemann-Pick Type C-2		Protection
D2	001,956	152	7	Niemann-Pick Type C-2		Protection
E2	002,848	148	14.3	Niemann-Pick Type C-2		Protection
C7	011,371	666	16.1	Tartan	Leucine-rich repeat protein	Protection
A8	007,031	748	14	FREP1	Pathogen recognition receptor	Protection
E8	004,918	305	4.3	Fibrinogen related protein	Pathogen recognition receptor	Protection
D3	013,327	602	12.4	HPX15	Response to oxidative stress	Protection
E4	005,093	2,175	5.8	Uncharacterized	Cadherin-like superfamily	Unknown
C8	001,193	143	3.1	Uncharacterized	CD59 Glycoprotein	Unknown
D6	008,138	510	4.4	Uncharacterized		Unknown
E5	006,972	113	25.7	Uncharacterized		Unknown
G7	000,014	328	11.1	Uncharacterized		Unknown

Idx: The position in Fig. 2A. ID: Gene access numbers follow the format of AGAP(NUMBER). AA: The number of amino acids. Folds: The folds of A₄₀₅ changes over negative control.