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. 2020 Aug 31;11:4358. doi: 10.1038/s41467-020-18199-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Firing rate of BLA MUA is not significantly different during 4 Hz and 8 Hz sinusoidal stimulation in the conditioned context (firing rate normalized to no light; paired two-tailed Wilcoxon test: P = 0.22, n = 50 MUA). b Same as in a but in unconditioned context (paired two-tailed Wilcoxon test: P = 0.33, n = 50 MUA). c Averaged PPC spectra (left) of BLA MUA during 4 Hz and 8 Hz optical stimulation in the conditioned context (Fear + Ext memory state). MUA phase-locking quantified as 4:8 Hz PPC ratio (right) is significantly shifted by 4 Hz vs. 8 Hz stimulation in the memory-context (paired two-tailed Wilcoxon test: P = 0.0005, n = 50 MUA). d Same as in c but in the unconditioned context (no memory state). MUA phase-locking is not significantly shifted by 4 Hz vs. 8 Hz stimulation in the unconditioned context (paired two-tailed Wilcoxon test: P = 0.17, n = 50 MUA). e Venn diagram showing the distribution of units significantly phase-locked to 4 Hz stimulus waveform in the conditioned (Fear + Ext) context (left), unconditioned neutral context (right), or both (middle overlap). f Proportion of units recruited to freezing-associated 4 Hz oscillations in the conditioned context is enriched among units that significantly phase-lock to 4 Hz stimulation in the conditioned context (Chi-square test: X² = 8.24, P = 0.0041, n = 17 units). g Same as e but for 8 Hz stimulation. h Proportion of units recruited to non-freezing-associated 8 Hz oscillations in the conditioned context among units that significantly phase-lock to 8 Hz stimulation in the conditioned versus unconditioned context (Chi-square test: X² = 1.94, P = 0.16, n = 14 units: one of the six Fear+Ext-only units in panel g did not meet the minimum number of spike criterium for PPC analysis during the non-freezing behavioral state). All error bars and shaded area: mean ± SEM.