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. Author manuscript; available in PMC: 2021 Feb 4.
Published in final edited form as: Sci Signal. 2020 Aug 4;13(643):eaay3258. doi: 10.1126/scisignal.aay3258

Fig. 4. Cell type–specific signaling characterization of the collagen-binding integrin signatures associated with anti-TNF resistance.

Fig. 4.

(A) Copy numbers of the indicated proteins from FACS-sorted immune cell populations (N = 3 or 4 donors). (B) TSNE of colonic CD biopsies (N = 5195 cells). (C) Differential expression of the genes ITGA1 and ITGB1 (which encode collagen-binding integrins) in the indicated cell populations [Kruskal-Wallis test; Epi, epithelial; Gob, goblet; Str, stromal (N = 5195 cells)]. (D) Network of significant ligand-receptor (LR) scores between intestinal and immune cell types containing at least one infliximab resistance signature gene (N = 5195 cells). Cell types are connected by edges indicating that a top-ranked (top 10% scores) LR interaction was present, whereas edge thickness indicates interaction strength. (E) Normalized LR scores within each pair of cell-cell interactions (N = 5195 cells).