Table 2.
Trial inclusion and exclusion criteria.
| Criteria | ||
| Inclusion | ||
|
|
Aged 18-64 years | |
|
|
Living in the state of California | |
|
|
BMI 27-43 kg/m2 | |
|
|
Must speak, read, and comprehend English | |
|
|
Must have a valid email address and phone number | |
|
|
Willingness to a follow an evidence-based very low carbohydrate diet or calorie-restricted diet that have been demonstrated for weight loss | |
|
|
Must have a kitchen and be willing to cook | |
|
|
Willingness to reduce (net) carbohydrate intake to less than 30 g/day | |
|
|
Willingness to restrict intake of added sugar, bread, grain, rice, pasta, sweets, most fruits, pastries, and other carbohydrates | |
|
|
Willingness to comply with a strict diet for 12 months | |
|
|
Interest in losing weight | |
|
|
(COVID-19a specific criteria) If you have been diagnosed with COVID-19, you may be eligible if: | |
|
|
|
Do not currently have COVID-19 related symptoms |
|
|
|
Your last symptoms were more than 4 weeks ago |
|
|
|
You experienced uncomplicated or mild COVID-19 symptoms |
|
|
|
You were not hospitalized because of your symptoms |
| Exclusion | ||
|
|
HIV or immunocompromised | |
|
|
Current or past cancer diagnosis | |
|
|
Pregnant, breastfeeding, or planned pregnancy in next 12 months | |
|
|
Beginning or ending hormonal contraception in next 12 months | |
|
|
Current diagnosis of diabetes | |
|
|
History of heart attack or stent | |
|
|
Currently taking glucose-lowering drugs, statins, or oral steroids | |
|
|
History of gastric bypass surgery or any other weight-loss surgery | |
|
|
History of anorexia or bulimia | |
|
|
History of mental illness | |
|
|
Current smoker or smoked cigarettes within past 12 months | |
|
|
Currently eating fewer than 50 g carbohydrates per day | |
|
|
Currently following ketogenic diet or have strictly adhered to a ketogenic diet for greater than 3 weeks in the past 6 months | |
|
|
Lost or gained more than 5% body weight in past 6 months | |
|
|
Currently using Weight Watchers or have strictly adhered to the WW app for greater than 3 weeks in the past 6 months | |
|
|
(COVID-19 specific criteria) If you have been diagnosed with COVID-19, you may be ineligible if: | |
|
|
|
You have had moderate to severe COVID-19 associated disease |
|
|
|
You have been hospitalized by COVID-19 |
aCOVID-19: coronavirus 2019 disease.