Table 2.

Results from included papers.

Events (n)	Patients (n)	Intervention	Outcome	Reference
2	400	patients who were treated with recommended dosages of the drug for a mean of 8.7 years	incidence of hydroxychloroquine-related retinopathy	Mavrikakis et al [15]
0	526	hydroxychloroquine	retinal toxicity was noted during the first 6 years of treatment	Mavrikakis et al [15]
46	845	chloroquine, hydroxychloroquine, or both	ophthalmological alterations, confirmed by the ophthalmological examination	Spinelli et al [16]
3	12	800 mg/day hydroxychloroquine	developed retinal toxicity with scotomas in the Amsler grid and Humphrey 10-2 automated perimetry, as well as abnormal multifocal electroretinography	Navajas et al [17]
0	11	long-term hydroxychloroquine	documented blindness, in all cases attributed to a cause other than hydroxychloroquine-related ocular toxicity	Singh et al [18]
35	678	hydroxychloroquine	had hydroxychloroquine toxicity	Chiu et al [19]
1	121	hydroxychloroquine	prevalence of toxic retinopathy	Cabral et al [20]
18	59	hydroxychloroquine	retinal toxicity was detected	Espandar et al [21]
9	778	antimalarial drugs	suffered definite presence of antimalarial retinopathy	Jover et al [22]
11	36	hydroxychloroquine	had abnormal response densities in one or both eyes	Maturi et al [23]
3	26	hydroxychloroquine	results from electrophysiological and clinical evaluation, toxicity (bull’s eye maculopathy)	Tzekov et al [24]
4	93	chloroquine and hydroxychloroquine therapy	developed typical bull’s eye maculopathy	Neubauer et al [25]