Table 3.
Study characteristics, pulled via artificial intelligence (see Multimedia Appendix 2 for the characteristics of all papers).
| Methodology Sentences | Time period | Cohort focus | Study type | Reference |
| The incidence of irreversible retinal toxicity in patients treated with hydroxychloroquine: a reappraisal. To define the risk of hydroxychloroquine (HCQ)-related retinal toxicity in patients with rheumatoid arthritis (rheumatoid arthritis) and systemic lupus erythematosus (systemic lupus erythematosus) who are receiving recommended dosages of the drug (< or =6.5 mg/kg/day). Prospective cohort study, from 1985 to 2000. Greek patients with rheumatoid arthritis (n=335) and systemic lupus erythematosus (n=191) treated with hydroxychloroquine, 400 of whom had completed at least 6 years of treatment. | Prospective | Drug Therapy | Observational | Mavrikakis et al [15] |
| Treating lupus patients with antimalarials: analysis of safety profile in a single-center cohort. This longitudinal retrospective study aims at describing the safety profile and the reasons for discontinuation of antimalarials in patients with systemic lupus erythematosus (systemic lupus erythematosus) and discoid lupus erythematosus (discoid lupus erythematosus), focusing on ocular toxicity. We analyzed the clinical data of 845 systemic lupus erythematosus and discoid lupus erythematosus patients; 59% of them were taking antimalarials: 1.4% chloroquine (chloroquine), 88.5% hydroxychloroquine (hydroxychloroquine) and 10.1% both. | Retrospective | Drug Therapy | Observational | Spinelli et al [16] |
| Retinal toxicity of high-dose hydroxychloroquine in patients with chronic graft-versus-host disease. To evaluate retinal toxicity in patients treated with high-dose hydroxychloroquine (hydroxychloroquine) (Plaquenil, Sanofi Pharmaceuticals) for chronic graft-versus-host disease (graft versus host disease). Twelve patients with chronic graft versus host disease treated with 800 mg/day hydroxychloroquine between June 2005 and December 2010. | Retrospective | Drug Therapy | Observational | Navajas et al [17] |