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. 2020 Jul 29;8(8):250. doi: 10.3390/biomedicines8080250

Figure 7.

Figure 7

Monomeric subunit of human ACAT2 protein (PDB code: 1WL4.A). Interaction surface in the tetramer as derived from the crystallographic coordinates is in orange. Interaction sites out the tetrameric interface, as predicted with ISPRED4 are in green. Positions in these regions carrying disease related variations (Table S4 (Supplementary Materials)) are highlighted with small spheres. Big spheres highlight positions in the protein carrying disease related variations (Table S4, for details) and promoting a large variance of folding free energy, as predicted with INPS [26]. Grey color: the background protein backbone.