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Days to (a) risk (n = 29), (b) injury (n = 25) and (c) failure (n = 17) based on the RIFLE criteria, from initiation of high-dose polymyxin B. The median times (IQR) to risk, injury and failure were 5 days (IQR, 4–7 days), 8 days (6–13 days) and 13 days (8–19 days), respectively.
