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Survival of mice over the course of the study. Kaplan–Meier survival curves of WT controls on the REG diet and vehicle (PBS) injections (black) and I278T mice on the MRD&Bet/REG/HMD diet (green/blue/red) receiving subcutaneously either PBS (solid lines) or OT-58 (10 mg/kg, dashed lines). The asterisk (*) designates significantly lower survival rate of I278T mice on the HMD diet receiving PBS compared to WT controls (65% versus 94.4%, Log-rank test p = 0.0303).
