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. 2020 Jul 24;8(8):244. doi: 10.3390/biomedicines8080244

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Necropsy and histopathology of deceased I278T mice on the HMD diet. Arrows point to the most common pathological findings identified in deceased I278T mice on the HMD diet and PBS injections: (a) blood-filled intestine, (b) blood cells in proximal duodenum, (c) caudal-ventral cerebral hemorrhage, (d) abnormal vacuoles in heart muscle, (e) inflamed heart vein, (f) microvesicular hepatosteatosis, (g) inflammation of liver parenchyma, (h) ductal hyperplasia of pancreas and (i) inflammation and destruction of normal pancreas parenchyma. Tissue sections were stained with H&E. Magnification varied and is indicated by a scale bar located in the bottom right corner of each panel.