Table 1.
Histological Parameter | Lesion Measurements; Mean ± SD Median (Min–Max) |
p-Value b | ||||
---|---|---|---|---|---|---|
Type I | Type II | Type III | Type IV | Type V a | ||
Width of border zone (µm) | 377.80 ± 64.53 375.99 302.87–487.18 |
391.83 ± 109.36 361.37 271.41–584.91 |
454.07 ± 127.49 416.34 286.74–672.44 |
334.27 ± 103.34 291.47 224.80–573.34 |
388.54 | 0.0621 |
Zone of epithelioid cells (µm) | 120.84 ± 26.24 128.02 70.01-165.28 |
127.76 ± 32.73 116.51 79.74-188.09 |
115.37 ± 21.98 110.23 90.67-154.85 |
147.88 ± 77.78 126.20 47.22–340.68 |
106.33 | 0.5965 |
Zone of fibrosis (µm) | 147.61 ± 35.27 153.27 87.71–195.12 |
147.52 ± 54.46 133.59 84.35–272.71 |
212.92 ± 113.66 169.03 101.90–461.28 |
102.74 ± 37.06 94.14 62.97–171.22 |
184.09 | 0.0089 ** |
Zone of lymphocytes (µm) | 109.36 ± 29.91 107.62 77.37–186.93 |
116.55 ± 55.23 109.73 69.88–267.44 |
125.78 ± 32.36 117.76 82.10–174.93 |
83.65 ± 33.71 74.12 38.96–159.10 |
98.13 | 0.0297 * |
Thickness of laminated layer fragments (µm) | 24.67 ± 7.36 23.89 12.64–37.41 |
22.85 ± 9.36 24.07 8.86–41.86 |
46.68 ± 57.17 22.64 15.68–193.32 |
27.14 ± 12.06 27.95 11.83-46.95 |
22.72 | 0.9000 |
Distance between laminated layer and border zone (µm) | 318.16 ± 266.48 264.80 28.00–926.92 |
464.26 ± 502.04 180.30 30.10–1266.50 |
756.60 ± 969.42 238.04 38.40–2479.60 |
2037.75 ± 968.43 1842.40 842.80–4533.80 |
120.62 | 0.0003 *** |
Spems in necrotic area (relative area covered by mAbEm2G11-positive stained spems in a single observation field; magnification 100×) | 0.51 ± 0.19 0.54 0.17–0.81 |
0.34 ± 0.24 0.23 0.07–0.68 |
0.38 ± 0.25 0.43 0.04–0.80 |
0.32 ± 0.20 0.31 0.01–0.66 |
- | 0.2621 |
* p < 0.05; ** p < 0.01; *** p < 0.001. a Type V was excluded from the analysis due to the small number of lesions. b p-values were calculated only for types I–IV.