Table 2.
Histological Parameter | Number of Lesions (Percent for Each Type) | p-Value b | |||||
---|---|---|---|---|---|---|---|
Type I | Type II | Type III | Type IV | Type V a | |||
Localisation of laminated layer fragments | Distributed throughout the necrotic area | 11 (100.00) | 11 (100.00) | 10 (100.00) | 1 (9.09) | 2 (100.00) | <0.0001 *** |
Centralised alveolae | 0 (0.00) | 0 (0.00) | 0 (0.00) | 10 (90.01) | 0 (0.00) | ||
Number of necrotic areas per section | Multiple necrotic areas | 10 (90.91) | 5 (45.45) | 7 (70.00) | 1 (9.09) | 1 (50.00) | 0.0010 ** |
Single necrotic area | 1 (9.09) | 6 (54.55) | 3 (30.00) | 10 (90.91) | 1 (50.00) | ||
Outer fibrotic rim (Zone 3b) | No fibrosis | 10 (90.91) | 10 (90.91) | 3 (30.00) | 11 (100.00) | 1 (50.00) | 0.0002 *** |
Fibrosis | 1 (9.09) | 1 (9.09) | 7 (70.00) | 0 (0.00) | 1 (50.00) | ||
Spems in necrotic area (scored 1–3) | 1 (spems only attached to the laminated layer) | 0 (0.00) | 0 (0.00) | 2 (20.00) | 2 (18.18) | 0 (0.00) | no p-value calculated |
2 (spems in entire necrotic area, but less abundant near the border) | 6 (54.55) | 7 (63.64) | 3 (30.00) | 6 (54.55) | 0 (0.00) | ||
3 (spems in entire necrotic area) | 5 (45.45) | 4 (36.36) | 5 (50.00) | 3 (27.27) | 2 (100.00) | ||
Spems in non-necrotic liver tissue | No spems | 2 (18.18) | 5 (45.45) | 1 (10.00) | 7 (63.64) | 0 (0.00) | 0.0348 * |
Spems | 9 (81.82) | 6 (54.55) | 9 (90.00) | 4 (36.36) | 2 (100.00) |
* p < 0.05; ** p < 0.01; *** p < 0.001. a Type V was excluded from the analysis due to the small n. b p-values were calculated only for types I–IV.