Table 3.
Antiradical activity and names of compounds in Scheme 3.
| No. | IC50/EC50 | Names |
|---|---|---|
| 3.1 | 9.52 ± 0.04 (a), 2.06 ± 0.08 (b) | 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol [83] |
| 3.2 | 7.43 ± 0.1 (a), 2.11 ± 0.04 (b) | 3,4-dibromo-5-((2,3-dihydroxypropoxy)methyl)benzene-1,2-dio [83] |
| 3.3 | 20.47 ± 0.07 (a), 1.87 ± 0.02 (b) | 5-(aminomethyl)-3,4-dibromobenzene-1,2-dio [83] |
| 3.4 | 19.84 ± 0.06 (a), 2.87 ± 0.11 (b) | 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid [83] |
| 3.5 | 50.58 ± 0.23 (a), 1.60 ± 0.04 (b) | 3-bromo-5-(hydroxymethyl)-2-methoxyphenol [83] |
| 3.6 | 8.72 ± 0.05 (a), 3.68 ± 0.12 (b) | (E)-4-(2-bromo-4,5-dihydroxyphenyl)but-3-en-2-one [83] |
| 3.7 | 8.5 (a) | (2R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)-cyclohexanone [84] |
| 3.8 | 20.3 (a) | 3-bromo-4,5-dihydroxybenzaldehyde [85] |
| 3.9 | 5.22 ± 0.04 (a), 2.87 ± 0.1 (b) | 3-(2,3-dibromo-4,5-dihydroxybenzyl)pyrrolidine-2,5-dione [92] |
| 3.10 | 5.70 ± 0.03 (a), 2.14 ± 0.08 (b) | Methyl 4-(2,3-dibromo-4,5-dihydroxybenzylamino)-4-oxobutanoate [92] |
| 3.11 | 5.43 ± 0.02 (a), 2.31 ± 0.11 (b) | 4-(2,3-dibromo-4,5-dihydroxybenzylamino)-4-oxobutanoic acid [92] |
| 3.12 | 23.60 ± 0.1 (a), 2.11 ± 0.04 (b) | 3-bbromo-5-hydroxy-4-methoxy-benzamide [92] |
| 3.13 | 20.81 ± 0.08 (a), 2.36 ± 0.08 (b) | 2-(3-bromo-5-hydroxy-4-methoxyphenyl)acetamide [92] |
| 3.14 | 14.5 (a), µg/mL | Methyl 4-(3-(2,3,6-tribromo-4,5-dihydroxybenzyl)ureido)butanoate [93] |
| 3.15 | 20.5 (a), µg/mL | 2-(3-(2,5-dibromo-3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)maleic acid [93] |
| 3.20 | 3.82 ± 0.01 (a), 4.37 ± 0.24 (b) | (R)-Rhodomelin A [44] |
| 3.21 | 8.90 (a) | (S)-Rhodomelin A [44] |
| 3.22 | 0.4 (c) | 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone [97] |
| 3.23 | 0.8 (c) | 2,3-dibromo-4,5-dihydroxydiphenylmethanone [97] |
| 3.24 | 0.9 (c) | 1-(4-(4-bromo-2-(2-bromo-4,5-dihydroxybenzoyl)benzyl)piperazin-1-yl)ethan-1-one [42] |
| 3.25 | 31.50 (a), 198.00 (b), µg/mL | (4-bromo-2,5-dimethoxyphenyl) (phenyl)methanone [81] |
| 3.26 | 28.87 (a), 231.00 (b), µg/mL | (3-bromo-4-methoxyphenyl) (3,4-dimethoxyphenyl)methanone [81] |
| 3.27 | 34.65 (a), 173.25 (b), µg/mL | (3-bromo-4-methoxyphenyl) (2,3-dibromo-4-hydroxy-5-methoxyphenyl)methanone [81] |
| 3.28 | 28.88 (a), 138.6 (b), µg/mL | (2,3-dibromo-4-hydroxy-5-methoxyphenyl) (2,5-dibromo-4-methoxyphenyl)methanone [81] |
| 3.29 | 26.65 (a), 231.00 (b), µg/mL | (3-bromo-4-methoxyphenyl) (2,5-dibromo-4-methoxyphenyl)methanone [81] |
| 3.30 | 23.10 (a), 69.3 (b), µg/mL | (2,5-dibromo-4-methoxyphenyl) (phenyl)methanone [81] |
| 3.31 | 33.00 (a), 115.50 (b), µg/mL | (3-bromo-4-hydroxyphenyl) (3,4-dihydroxyphenyl)methanone [81] |
| 3.32 | 16.44 (a), 6.55 (b), µg/mL | (4-bromo-2,5-dihydroxyphenyl) (3, 4-dihydroxyphenyl)methanone [96] |
| 3.33 | 14.43 (a), 6.86 (b), µg/mL | (4-bromo-2,5-dihydroxyphenyl) (3,4,5-trihydroxyphenyl)methanone [96] |
| 3.34 | 19.24 (a), 7.35 (b), µg/mL | (2-bromo-4-hydroxyphenyl) (4-hydroxyphenyl)methanone [96] |
| 3.35 | 13.32 (a), 6.86 (b), µg/mL | 2-benzyl-5-bromobenzene-1,4-diol [96] |
| 3.36 | 13.86 (a), 5.08 (b), µg/mL | 2-bromo-5-(4-hydroxybenzyl)benzene-1,4-diol [96] |
| 3.37 | 15.75 (a), 7.71 (b), µg/mL | 4-(2-bromo-4-hydroxybenzyl)benzene-1,2-diol [96] |
Notes: a, IC50 for DPPH inhibition, and unit for IC50 is µM, unless labeled as µg/mL; b, IC50 for TEAC inhibition and unit for IC50 is mM, unless labeled as µg/mL; c, EC50 (μM) for H2O2 inhibition.