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. 2020 Aug 16;10(8):1432. doi: 10.3390/ani10081432

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathological lesions in liver of naturally diseased Nile tilapia showing (a) hepatocellular dissociation (thin arrow) with many necrotic and apoptotic cells (thick arrow). Few rod-shaped bacteria are inside a hepatocyte cytoplasmic vacuole (green arrows). H&E (hematoxylin and eosin), 400×; (b) Widespread hepatocellular necrosis (black arrows) with diffuse, numerous rod-shaped bacteria (green arrows). H&E, 400×; (c) Diffuse, severe necrotizing hepatitis. See widespread, severe hepatocellular lysis (arrows) with few bacteria (green arrow) and widespread infiltrations with numerous macrophages and lymphocytes (thick arrow). H&E, 400×; (d) Hepatopancreatitis with edema widely separated lytic hepatocytes (arrows) and lysis of hepatopancreas (green arrow) and focal aggregations of inflammatory cells (thick arrow).