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. 2020 Jul 24;8(8):243. doi: 10.3390/biomedicines8080243

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The proposed mechanism of the connection between GPR120 insensitivity and impaired lipid metabolism in schizophrenia. In healthy individuals, GPR120 activation leads to anti-inflammatory effects. Natural ligands (DHA and ALA) stimulate GPR120–β-arrestin complex formation and drive phospholipase A2 (PLA2) activation. Pro-/anti-inflammatory homeostasis is maintained. In schizophrenia patients, GPR120 insensitivity leads to pro/anti-inflammatory imbalance. Natural ligands (DHA and ALA) are unable to stimulate GPR120–β-arrestin complex formation. Overactivity of PLA2 causes a switch to inflammatory pathway stimulation. Pro-/anti-inflammatory homeostasis is disturbed.