Fig. 2.

Anti-inflammatory mechanism triggered by YojI-IFNAR2 and YojI-IL10RA membrane protein interactions. a YojI-IFNAR2 and YojI-IL10RA membrane protein interaction induces the anti-inflammatory responses of HBMECs, because the NLRP2 gene inhibits inflammasome-dependent autophagy. NLR oligomerization activates NF-kB activity for the transcription of IL-1β, and mediates caspase-1 cleavage of pro-inflammatory factor IL-1β to the mature IL-1β. b IFN-α/β binding to IFNAR triggers inflammasome activation and inflammatory responses