Fig. 6.

High-throughput construction of a liquid electrochemical sensor integrated with recombinant membrane protein virions for HTS of anti-infective and anti-inflammatory drugs (2019-novel coronavirus/human/bacteria) and clinical diagnosis of inflammatory diseases. a Molecular drugs target different sites of transmembrane proteins: small drugs bind the extracellular domain of IFNAR2, N-terminal domain or different loops of seven-transmembrane domain protein receptor G2A (loop i, loop ii, loop iii); the membrane protein interaction between Spike (trimer) and ACE2 (dimer). b The IFNAR2/ACE2/Spike and GPCR-recombinant herpes virion solution (IFNAR2/ACE2/Spike-HSV-1 and GPCR-HSV-1) can be applied to fabricate the new virion liquid electrochemical sensor for HTS of anti-inflammatory drugs or clinical diagnosis and treatment of inflammatory diseases, especially for the prevention and cure of 2019-novel coronavirus pneumonia