CLSM examination of S. mutans (Sm) and C. albicans (Ca) single and mixed-species biofilm formation in the presence of Lactobacillus plantarum 108 supernatant (Sup). The biofilms were fixed and stained with calcofluor white for C. albicans (in blue) and propidium iodide for S. mutans (in red). Images A–C shows S. mutans single-species biofilms (A) control group, (B) treated with supernatant at 0 h, (C) preformed biofilm treated with the supernatant at 12 h. Images D–F shows C. albicans single-species biofilms (D) control group, (E) treated with supernatant at 0h, (F) preformed biofilm treated with the supernatant at 12 h. Images G–I shows S. mutans and C. albicans mixed-species biofilms (G) Control group, (H) treated with supernatant at 0 h, (I) preformed biofilm treated with the supernatant at 12 h.