Figure 2.

Schematic representation of the proposed two-step mechanism concerning the membrane disruption by hIAPP [5] and Aβ [7] through membrane fragmentation (detergent-like) and ion-channel-like pore formation. In the time scale, pore formation occurs before the detergent-like mechanism, where fibril grow on the bilayer’s surface by removing lipids from one leaflet (carpeting) and then ripping the remaining leaflet (detergent) with consequent membrane damage.