Table 2.
Serum antibody levels in response to five periodontal pathogens and lipopolysaccharide (LPS) levels according to the CRS.
| Antigen/Measure | Antibody Class | CRS I n = 117 | CRS II n = 162 | CRS III n = 166 | p-Value 1 | OR for High CRS (95% CI), p-Value 2 | |
|---|---|---|---|---|---|---|---|
| Median (IQR) | Model 1 | Model 2 | |||||
| Aggregatibacter actinomycetemcomitans | IgA | 0.61 (0.61) | 0.59 (0.67) | 0.69 (0.69) | 0.037 | 2.22 (1.19–4.18), 0.012 | 2.39 (1.27–4.52), 0.007 |
| IgG | 0.60 (0.50) | 0.69 (0.80) | 0.73 (0.77) | 0.043 | 1.66 (0.92–3.00), 0.094 | ||
| Porphyromonas gingivalis | IgA | 0.24 (0.98) | 0.33 (0.91) | 0.86 (1.41) | <0.001 | 2.88 (1.89–4.38) <0.001 | 1.47 (0.92–2.35), 0.106 |
| IgG | 0.84 (1.47) | 0.95 (1.37) | 1.71 (1.88) | <0.001 | 7.34 (3.65–14.7), <0.001 | 2.32 (1.04–5.18), 0.040 | |
| Porphyromonas endodontalis | IgA | 0.33 (0.55) | 0.45 (0.61) | 0.65 (1.26) | <0.001 | 3.52 (2.03–6.09), <0.001 | 2.95 (1.66–5.21), <0.001 |
| IgG | 0.97 (1.31) | 1.12 (1.17) | 1.79 (1.66) | <0.001 | 7.41 (3.36–16.3), <0.001 | 6.08 (2.94–12.3), <0.001 | |
| Prevotella intermedia | IgA | 0.56 (0.41) | 0.56 (0.44) | 0.68 (0.60) | 0.013 | 3.11(1.43–6.74), 0.004 | 2.59 (1.15–5.81), 0.021 |
| IgG | 0.44 (0.35) | 0.42 (0.28) | 0.46 (0.35) | 0.295 | 2.30 (1.01–5.22), 0.047 | 1.87 (0.79–4.42), 0.154 | |
| Tannerella forsythia | IgA | 0.23 (0.16) | 0.18 (0.12) | 0.19 (0.14) | 0.114 | 1.28 (0.65–2.53), 0.474 | |
| IgG | 0.12 (0.13) | 0.10 (0.11) | 0.10 (0.12) | 0.203 | 1.06 (0.57–1.97), 0.855 | ||
| LPS | 0.46 (0.43) | 0.54 (0.62) | 0.53 (0.58) | 0.123 | 1.23 (0.68–2.22), 0.497 | ||
1 Jonckheere–Terpstra test; 2 logistic regression models, dependent variable CRS III vs. CRSI–II, odds ratio (OR) is presented/10-base logarithmically transformed unit; Model 1, adjusted for age, gender, and number of remaining teeth; Model 2, additionally adjusted for the subgingival level of the species. The antibody levels are presented as absorbance units, AU. The LPS activity is presented as endotoxin units, EU/mL. Statistically significant p-values are indicated by bold face.