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. 2020 Aug 5;10(8):138. doi: 10.3390/life10080138

Table 4.

Summary of performance for each method at various cutoff points when the total sample size = 300,000 and rr~U1.2, 4.

True Signal Ratio 0.03 0.05 0.1
Method Cutoff * Power Sensitivity PPV Power Sensitivity PPV Power Sensitivity PPV
ROR 1 0.987 0.518 0.164 0.997 0.510 0.262 0.995 0.464 0.437
1.5 0.984 0.419 0.250 0.997 0.408 0.364 0.995 0.362 0.531
2 0.971 0.323 0.316 0.996 0.313 0.437 0.995 0.268 0.581
2.5 0.934 0.243 0.348 0.984 0.231 0.468 0.994 0.190 0.597
3 0.864 0.177 0.353 0.943 0.163 0.467 0.984 0.133 0.591
PRR 1 0.987 0.518 0.164 0.997 0.510 0.262 0.995 0.464 0.437
1.5 0.984 0.419 0.250 0.997 0.408 0.364 0.995 0.361 0.532
2 0.971 0.322 0.317 0.996 0.312 0.437 0.995 0.267 0.582
2.5 0.933 0.241 0.349 0.984 0.229 0.469 0.994 0.189 0.597
3 0.861 0.175 0.354 0.940 0.162 0.467 0.983 0.132 0.591
IC log21 0.944 0.472 0.182 0.984 0.469 0.290 0.984 0.413 0.486
log21.5 0.901 0.334 0.378 0.969 0.331 0.527 0.976 0.284 0.702
log22 0.835 0.222 0.582 0.942 0.217 0.696 0.965 0.179 0.811
log22.5 0.782 0.175 0.662 0.905 0.165 0.759 0.946 0.129 0.850
log23 0.569 0.087 0.744 0.716 0.077 0.820 0.828 0.056 0.882
LRT 0.2 0.673 0.149 0.867 0.785 0.136 0.917 0.859 0.111 0.955
0.1 0.602 0.122 0.911 0.725 0.111 0.948 0.815 0.089 0.981
0.05 0.554 0.104 0.939 0.670 0.091 0.975 0.748 0.071 0.988
0.025 0.509 0.088 0.966 0.609 0.077 0.984 0.679 0.057 0.992
0.01 0.444 0.071 0.977 0.534 0.060 0.987 0.612 0.044 0.999
GPS 1 0.430 0.079 0.983 0.611 0.095 0.989 0.704 0.090 0.992
1.5 0.051 0.008 1.000 0.250 0.026 0.996 0.561 0.047 0.999
2 0.028 0.005 1.000 0.165 0.017 1.000 0.465 0.034 0.999
2.5 0.015 0.002 1.000 0.065 0.005 1.000 0.057 0.002 1.000
3 0.003 0.000 1.000 0.008 0.001 1.000 0.003 0.000 1.000
BCPNN log21 0.864 0.306 0.477 0.914 0.292 0.624 0.943 0.259 0.802
log21.5 0.640 0.135 0.915 0.745 0.121 0.937 0.824 0.098 0.976
log22 0.339 0.048 0.984 0.426 0.040 0.996 0.507 0.028 1.000
log22.5 0.113 0.013 1.000 0.140 0.010 1.000 0.166 0.006 1.000
log23 0.022 0.003 1.000 0.026 0.002 1.000 0.025 0.001 1.000
sB 1 0.669 0.171 0.860 0.743 0.161 0.927 0.778 0.133 0.969
1.5 0.472 0.080 0.991 0.569 0.072 0.995 0.628 0.052 0.997
2 0.247 0.031 0.996 0.294 0.024 1.000 0.345 0.015 1.000
2.5 0.084 0.009 1.000 0.094 0.006 1.000 0.098 0.003 1.000
3 0.016 0.002 1.000 0.021 0.001 1.000 0.018 0.001 1.000
TreeScan 0.2 0.671 0.148 0.866 0.772 0.137 0.919 0.843 0.110 0.945
0.1 0.619 0.125 0.930 0.726 0.114 0.965 0.792 0.088 0.964
0.05 0.573 0.107 0.961 0.671 0.096 0.982 0.729 0.073 0.983
0.025 0.520 0.092 0.970 0.614 0.082 0.990 0.685 0.061 0.991
0.01 0.452 0.074 0.985 0.550 0.065 0.993 0.609 0.048 0.995

ROR, Reporting Odds Ratio; PRR, Proportional Reporting Ratio; IC, Information Component; LRT, Likelihood ratio test; GPS, Gamma Poisson Shrinker; BCPNN, Bayesian Confidence Propagation Neural Network; sB simplified Bayes; TreeScan, Tree-based Scan Statistic; * Cutoff values for the lower bound of the 95% CI for ROR, PRR, IC, BCPNN, and sB, for EB05 for GPS, and for the p-value for LRT and TreeScan.