Table 9.
Adverse Event | Obs | Exp | ROR | PRR | IC | LRT | GPS | BCPNN | sB | TreeScan | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Voglibose | 500_165 | Anorexia | 8 | 2.62 | 2.42 * | 2.42 * | 0.59 | 0.940 | 1.12 | 0.35 | 1.37 | 0.504 |
600 | Gastrointestinal system disorders | 115 | 73.73 | 1.83 | 1.83 | 0.32 | 0.001 * | 1.28 | 0.31 | 1.46 | 0.001 * | |
600_204 | Constipation | 11 | 3.96 | 2.26 * | 2.26 * | 0.60 | 0.782 | 1.24 | 0.43 | 1.47 | 0.336 | |
600_205 | Diarrhea | 12 | 6.43 | 1.33 | 1.33 | 0.06 | 1.000 | 0.92 | 0.00 | 1.23 | 0.980 | |
600_268 | Abdominal pain | 10 | 3.63 | 2.20 * | 2.20 * | 0.55 | 0.910 | 1.17 | 0.37 | 1.43 | 0.447 | |
600_279 | Dyspepsia | 35 | 7.22 | 5.16 * | 5.15 * | 1.77 * | 0.001 * | 3.11 * | 1.62 * | 3.64 * | 0.001 * | |
600_285 | Flatulence | 15 | 0.39 | 40.28 * | 40.00 * | 4.49 * | 0.001 * | 20.89 * | 2.79 * | 10.76 * | 0.001 * | |
800 | Metabolic and nutritional disorders | 37 | 5.07 | 8.11 * | 8.10 * | 2.37 * | 0.001 * | 4.67 * | 2.15 * | 6.11 * | 0.001 * | |
800_389 | Hypoglycemia | 24 | 0.55 | 48.25 * | 47.86 * | 4.84 * | 0.001 * | 27.47 * | 3.41 * | 17.12 * | 0.001 * | |
800_392 | Hyponatremia | 2 | 0.18 | 9.67 * | 9.65 * | 1.44 * | 0.996 | 0.49 | −0.30 | 0.03 | 0.772 | |
800_407 | Weight decrease | 2 | 0.21 | 8.19 * | 8.18 * | 1.24 * | 0.998 | 0.47 | −0.34 | 0.04 | 0.860 | |
1100 | Respiratory system disorders | 16 | 9.46 | 1.23 | 1.23 | 0.03 | 1.000 | 0.94 | −0.02 | 1.21 | 0.981 | |
1100_515 | Epistaxis | 2 | 0.21 | 8.18 * | 8.17 * | 1.24 * | 0.998 | 0.47 | −0.34 | 0.04 | 0.861 | |
1100_523 | Pharyngitis | 4 | 0.85 | 3.79 * | 3.79 * | 0.81 | 0.992 | 0.85 | 0.15 | 0.80 | 0.745 | |
1810_401 | Edema peripheral | 3 | 0.71 | 3.15 * | 3.15 * | 0.44 | 1.000 | 0.60 | −0.20 | 0.43 | 0.973 | |
Acarbose | 500_172 | Depression | 2 | 0.08 | 25.07 * | 25.02 * | 2.68 * | 0.638 | 0.66 | −0.18 | 0.04 | 0.209 |
600_205 | Diarrhea | 7 | 3.01 | 1.65 | 1.64 | 0.11 | 1.000 | 0.84 | −0.05 | 0.90 | 0.924 | |
600_285 | Flatulence | 12 | 0.18 | 72.43 * | 72.02 * | 5.16 * | 0.001 * | 31.93 * | 2.62 * | 10.06 * | 0.001 * | |
600_336 | Tooth disorder | 2 | 0.01 | 180.65 * | 177.84 * | 5.43 * | 0.010 * | 1.88 | −0.10 | 0.02 | 0.008 * | |
800 | Metabolic and nutritional disorders | 6 | 2.38 | 1.79 | 1.79 | 0.15 | 1.000 | 0.81 | −0.06 | 0.89 | 0.920 | |
800_383 | Hyperkalemia | 2 | 0.11 | 17.08 * | 17.06 * | 2.16 * | 0.846 | 0.58 | −0.22 | 0.03 | 0.390 | |
800_389 | Hypoglycemia | 3 | 0.26 | 10.77 * | 10.76 * | 1.88 * | 0.632 | 0.91 | 0.23 | 0.64 | 0.202 | |
1210 | Red blood cell disorders | 4 | 0.62 | 5.70 * | 5.70 * | 1.26 * | 0.798 | 1.00 | 0.33 | 0.98 | 0.326 | |
1210_544 | Anemia | 4 | 0.51 | 7.13 * | 7.13 * | 1.54 * | 0.556 | 1.10 | 0.43 | 1.05 | 0.176 | |
1300 | Urinary system disorders | 6 | 2.16 | 2.06 * | 2.06 * | 0.29 | 0.998 | 0.87 | 0.04 | 0.91 | 0.819 | |
1300_619 | Renal function abnormal | 2 | 0.11 | 16.52 * | 16.50 * | 2.12 * | 0.860 | 0.57 | −0.23 | 0.03 | 0.396 | |
1810_711 | Abdomen enlarged | 2 | 0.08 | 25.76 * | 25.71 * | 2.72 * | 0.632 | 0.66 | −0.18 | 0.02 | 0.197 |
Obs, Observed count; Exp, Expected count; ROR, Reporting Odds Ratio; PRR, Proportional Reporting Ratio; IC, Information Component; LRT, Likelihood ratio test; GPS, Gamma Poisson Shrinker; BCPNN, Bayesian Confidence Propagation Neural Network; sB simplified Bayes; TreeScan, Tree-based Scan Statistic; * signal.