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. 2020 Aug 5;10(8):138. doi: 10.3390/life10080138

Table 9.

Detected signals by each method for voglibose and acarbose.

Adverse Event Obs Exp ROR PRR IC LRT GPS BCPNN sB TreeScan
Voglibose 500_165 Anorexia 8 2.62 2.42 * 2.42 * 0.59 0.940 1.12 0.35 1.37 0.504
600 Gastrointestinal system disorders 115 73.73 1.83 1.83 0.32 0.001 * 1.28 0.31 1.46 0.001 *
600_204 Constipation 11 3.96 2.26 * 2.26 * 0.60 0.782 1.24 0.43 1.47 0.336
600_205 Diarrhea 12 6.43 1.33 1.33 0.06 1.000 0.92 0.00 1.23 0.980
600_268 Abdominal pain 10 3.63 2.20 * 2.20 * 0.55 0.910 1.17 0.37 1.43 0.447
600_279 Dyspepsia 35 7.22 5.16 * 5.15 * 1.77 * 0.001 * 3.11 * 1.62 * 3.64 * 0.001 *
600_285 Flatulence 15 0.39 40.28 * 40.00 * 4.49 * 0.001 * 20.89 * 2.79 * 10.76 * 0.001 *
800 Metabolic and nutritional disorders 37 5.07 8.11 * 8.10 * 2.37 * 0.001 * 4.67 * 2.15 * 6.11 * 0.001 *
800_389 Hypoglycemia 24 0.55 48.25 * 47.86 * 4.84 * 0.001 * 27.47 * 3.41 * 17.12 * 0.001 *
800_392 Hyponatremia 2 0.18 9.67 * 9.65 * 1.44 * 0.996 0.49 −0.30 0.03 0.772
800_407 Weight decrease 2 0.21 8.19 * 8.18 * 1.24 * 0.998 0.47 −0.34 0.04 0.860
1100 Respiratory system disorders 16 9.46 1.23 1.23 0.03 1.000 0.94 −0.02 1.21 0.981
1100_515 Epistaxis 2 0.21 8.18 * 8.17 * 1.24 * 0.998 0.47 −0.34 0.04 0.861
1100_523 Pharyngitis 4 0.85 3.79 * 3.79 * 0.81 0.992 0.85 0.15 0.80 0.745
1810_401 Edema peripheral 3 0.71 3.15 * 3.15 * 0.44 1.000 0.60 −0.20 0.43 0.973
Acarbose 500_172 Depression 2 0.08 25.07 * 25.02 * 2.68 * 0.638 0.66 −0.18 0.04 0.209
600_205 Diarrhea 7 3.01 1.65 1.64 0.11 1.000 0.84 −0.05 0.90 0.924
600_285 Flatulence 12 0.18 72.43 * 72.02 * 5.16 * 0.001 * 31.93 * 2.62 * 10.06 * 0.001 *
600_336 Tooth disorder 2 0.01 180.65 * 177.84 * 5.43 * 0.010 * 1.88 −0.10 0.02 0.008 *
800 Metabolic and nutritional disorders 6 2.38 1.79 1.79 0.15 1.000 0.81 −0.06 0.89 0.920
800_383 Hyperkalemia 2 0.11 17.08 * 17.06 * 2.16 * 0.846 0.58 −0.22 0.03 0.390
800_389 Hypoglycemia 3 0.26 10.77 * 10.76 * 1.88 * 0.632 0.91 0.23 0.64 0.202
1210 Red blood cell disorders 4 0.62 5.70 * 5.70 * 1.26 * 0.798 1.00 0.33 0.98 0.326
1210_544 Anemia 4 0.51 7.13 * 7.13 * 1.54 * 0.556 1.10 0.43 1.05 0.176
1300 Urinary system disorders 6 2.16 2.06 * 2.06 * 0.29 0.998 0.87 0.04 0.91 0.819
1300_619 Renal function abnormal 2 0.11 16.52 * 16.50 * 2.12 * 0.860 0.57 −0.23 0.03 0.396
1810_711 Abdomen enlarged 2 0.08 25.76 * 25.71 * 2.72 * 0.632 0.66 −0.18 0.02 0.197

Obs, Observed count; Exp, Expected count; ROR, Reporting Odds Ratio; PRR, Proportional Reporting Ratio; IC, Information Component; LRT, Likelihood ratio test; GPS, Gamma Poisson Shrinker; BCPNN, Bayesian Confidence Propagation Neural Network; sB simplified Bayes; TreeScan, Tree-based Scan Statistic; * signal.