Table 1.
Patient characteristics: overall and by line of treatment (results on continuous data are reported in italics).
| Overall | Line I | Line II | |||||
|---|---|---|---|---|---|---|---|
| Characteristics | No. | (%) | No. | (%) | No. | (%) | p-Value |
| Total patients | 71 | (100.0) | 48 | (100.0) | 23 | (100.0) | |
| Patient age at diagnosis | 55.0 (17.0) | 56.5 (17.3) | 53.0 (15.5) | 0.486 a | |||
| Patient age at start of therapy | 60.0 (16.5) | 59.5 (16.3) | 53.0 (15.5) | 0.777 a | |||
| Histology | |||||||
| Ductal | 53 | (75.7) | 34 | (70.8) | 19 | (83.4) | 0.110 b |
| Lobular | 11 | (15.7) | 9 | (18.8) | 2 | (9.0) | |
| Other | 5 | (4.5) | 5 | (10.4) | 0 | (0.0) | |
| Ductal and lobular | 1 | (1.4) | 0 | (0.0) | 1 | (4.5) | |
| Unknown | 1 | 1 | |||||
| Surgery | |||||||
| Yes | 55 | (78.6) | 36 | (75.0) | 19 | (86.4) | 0.479 b |
| No | 15 | (21.4) | 12 | (25.0) | 3 | (13.6) | |
| Unknown | 1 | 1 | |||||
| Surgery type c | |||||||
| Mastectomy | 28 | (50.9) | 17 | (52.8) | 11 | (57.9) | 0.437 b |
| Conservative | 27 | (49.1) | 19 | (47.2) | 8 | (42.1) | |
| PR | 45.0 (18.5) | 50.0 (85.5) | 37.5 (67.5) | 0.368 a | |||
| Low (<20%) | 26 | (38.8) | 17 | (36.2) | 9 | (45.0) | 0.431 b |
| High (≥20%) | 41 | (61.2) | 30 | (63.8) | 11 | (55.0) | |
| Unknown | 4 | 1 | 3 | ||||
| Ki67 | 15.0 (15.0) | 15.0 (11.5) | 25.0 (14.5) | 0.047 a | |||
| Low (<20%) | 37 | (56.1) | 31 | (66.0) | 6 | (31.6) | 0.063 b |
| High (≥20%) | 29 | (43.9) | 16 | (34.0) | 13 | (68.4) | |
| Unknown | 5 | 1 | 4 | ||||
| Luminal subtype | |||||||
| A | 24 | (36.4) | 22 | (46.8) | 2 | (10.5) | 0.005 b |
| B | 42 | (63.6) | 25 | (53.2) | 17 | (89.5) | |
| Unknown | 5 | 1 | 4 | ||||
| Stage (at diagnosis) | |||||||
| I | 14 | (23.7) | 12 | (27.9) | 2 | (12.5) | 0.347 b |
| II | 19 | (32.2) | 11 | (25.6) | 8 | (50.0) | |
| III | 16 | (27.1) | 12 | (27.9) | 4 | (25.0) | |
| IV | 10 | (16.9) | 8 | (18.6) | 2 | (12.5) | |
| Unknown | 12 | 5 | 7 | ||||
a Mann–Whitney–Wilcoxon test for differences in the median with respect to treatment line; b Fisher exact test for association with line of treatment (histology and stage p-values are obtained with 100,000 Monte Carlo replication); c out of the corresponding patients who underwent surgery.