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. 2020 Jul 31;10(8):1323. doi: 10.3390/ani10081323

Table 2.

Coefficient estimates (standard errors) and p-values for time and group on pH, venous partial pressure of carbon dioxide (PCO2), bicarbonate (HCO3−), base excess (BE), anion gap (AG), lactate, measured strong ion difference (SIDm), non-volatile weak acids (Atot), strong ion gap (SIG) and plasma osmolality. Time: capture (TC), start of transport (T0), and two (T2), four (T4) and six (T6) hours of transport. Groups: midazolam (Group M), azaperone (Group A). Reference category: Group A Time T0. The star indicates statistical significance (p < 0.05).

pH PCO2 (mmHg) HCO3− (mmol/L) BE (mmol/L) AG (mmol/L) Lactate (mmol/L) SIDm (mmol/L) Atot (mmol/L) SIG (mmol/L) Osmolality (mOsm/kg)
Group M −0.011 −0.986 −1.358 −1.462 1.068 1.392 −1.593 −0.527 −1.572 2.502
(0.027) (3.300) (1.486) (1.748) (1.243) (1.070) (1.423) (0.390) (1.475) (3.314)
p = 0.695 p = 0.766 p = 0.362 p = 0.403 p = 0.391 p = 0.193 p = 0.263 p = 0.177 p = 0.287 p = 0.451
Time TC −0.332 * 23.645 * −10.218 * −15.573 * 8.818 * 9.657 * −10.845 * 2.068 * −9.160 * 4.735 *
(0.028) (3.188) (1.391) (1.661) (1.208) (1.025) (1.357) (0.222) (1.404) (1.176)
p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001
Time T2 0.002 1.573 0.873 0.945 −1.182 −0.372 0.023 0.433 1.559
(0.028) (3.188) (1.391) (1.661) (1.208) (1.025) (1.357) (0.222) (1.404)
p = 0.933 p = 0.622 p = 0.531 p = 0.570 p = 0.329 p = 0.717 p = 0.987 p = 0.052 p = 0.267
Time T4 0.038 −3.518 0.036 0.664 0.182 0.028 0.069 0.219 0.164
(0.028) (3.188) (1.391) (1.661) (1.208) (1.025) (1.357) (0.222) (1.404)
p = 0.169 p = 0.270 p = 0.980 p = 0.690 p = 0.881 p = 0.979 p = 0.960 p = 0.325 p = 0.908
Time T6 0.033 −3.782 −0.782 −0.264 0.727 0.072 −0.337 −0.084 −0.670 0.476
(0.028) (3.188) (1.391) (1.661) (1.208) (1.025) (1.357) (0.222) (1.404) (1.135)
p = 0.241 p = 0.236 p = 0.574 p = 0.874 p = 0.548 p = 0.945 p = 0.804 p = 0.706 p = 0.634 p = 0.675
Group M:
Time TC		 0.098 * −6.879 3.577 5.106 * −5.152 * −4.610 * 3.085 0.178 6.013 * −4.075 *
(0.039) (4.413) (1.925) (2.300) (1.673) (1.419) (1.879) (0.308) (1.943) (1.602)
p = 0.012 p = 0.120 p = 0.064 p = 0.027 p = 0.003 p = 0.002 p = 0.101 p = 0.563 p = 0.002 p = 0.011
Group M:
Time T2		 0.030 −2.673 0.386 0.763 0.108 −1.083 1.276 −0.099 0.951
(0.039) (4.413) (1.925) (2.300) (1.692) (1.419) (1.901) (0.308) (1.943)
p = 0.437 p = 0.545 p = 0.842 p = 0.741 p = 0.950 p = 0.446 p = 0.503 p = 0.748 p = 0.625
Group M:
Time T4		 −0.0001 1.485 1.014 0.936 −0.848 −0.896 1.021 −0.092 0.773
(0.039) (4.413) (1.925) (2.300) (1.673) (1.419) (1.879) (0.308) (1.943)
p = 0.998 p = 0.737 p = 0.599 p = 0.684 p = 0.613 p = 0.528 p = 0.587 p = 0.766 p = 0.691
Group M:
Time T6		 0.011 1.873 2.173 3.230 −1.165 −1.123 2.607 0.333 3.078 −2.475
(0.039) (4.413) (1.925) (2.300) (1.692) (1.419) (1.927) (0.312) (1.966) (1.572)
p = 0.775 p = 0.672 p = 0.259 p = 0.161 p = 0.492 p = 0.429 p = 0.177 p = 0.286 p = 0.118 p = 0.116
Constant 7.441 * 49.636 * 33.891 * 9.745 * 12.182 * 2.381 * 46.029 * 15.457 * 1.119 286.265 *
(0.020) (2.384) (1.074) (1.263) (0.898) (0.773) (1.028) (0.282) (1.066) (2.393)
p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.001 p = 0.003 p < 0.001 p < 0.001 p = 0.294 p < 0.001
Observations 115 115 115 115 113 115 112 114 114 68
LL 124.934 −377.299 −292.391 −310.037 −269.919 −258.737 −280.524 −118.074 −289.566 −189.428
AIC −225.868 778.597 608.782 644.074 563.837 541.474 585.048 260.147 603.131 394.857