Table 2.
MIC values (μg/mL) of cadiolides B–N (112–124).
| Compounds | MIC (μg/mL) | ||||
|---|---|---|---|---|---|
| A a | B a | C a | D a | E a | |
| cadiolide B (112) | 3.1 | 3.1 | 3.1 | >128 | >128 |
| cadiolide C (113) | 0.4 | 0.2 | 3.1 | 64 | >128 |
| cadiolide D (114) | 6.3 | 1.6 | 6.3 | >128 | >128 |
| cadiolide E (115) | 3.1 | 0.2 | 1.6 | 1.6 | 3.1 |
| cadiolide F (116) | 12.5 | 3.1 | 12.5 | - b | - b |
| cadiolide G (117) | 3.1 | 3.1 | 12.5 | 0.8 | 3.1 |
| cadiolide H (118) | 6.3 | 3.1 | 1.6 | 3.1 | 3.1 |
| cadiolide I (119) | 0.8 | 0.8 | 0.8 | 1.6 | 6.3 |
| cadiolide J (120) | 32 | - b | - b | 64 | 8 |
| cadiolide K (121) | 8 | - b | - b | 8 | 4 |
| cadiolide L (122) | 2 | - b | - b | 4 | 2 |
| cadiolide M (123) | 1 | - b | - b | - b | - b |
| cadiolide N (124) | 16 | - b | - b | 16 | 16 |
a A: S. aureus; B: K. rhizophila; C: B. subtilis; D: S. enterica; E: Proteus hauseri; b the symbol “-” means that the compound has not been tested yet.