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. 2020 Aug 1;10(8):131. doi: 10.3390/life10080131

Figure 2.

Figure 2

LncRNAs in cells of kidney. LncRNAs regulate cell viability, proliferation, migration, activation, autophagy, and apoptosis, as well as facilitates the production of ECM. (Myo) Fibroblast: Down-regulated GAS5 promotes proliferation and the expression of collagen α1A (collα1A) and α-SMA. Down-regulated Miat decreases the expression of α-smooth muscle actin (α-SMA), collα1, SMAD2, and SMAD3 while the silencing of Rian causes the opposite effect. Pericyte: The knockdown of HypERlnc increases cell viability and proliferation, but decreases cell recruitment. Pericyte loss appeared along with the silence of MALAT1. Podocyte: CmASC15 up-regulated and LINC01619 down-regulated increase apoptosis. Up-regulation of HOTAIR increases the expression of collagen IV and α-SMA. Overexpression of PVT1 promotes cell damage, apoptosis, and the expression of TGF-β1 and fibronectin (FN). PRINS up-regulated decreases cell viability, but increases Smad7, cell damage, and apoptosis. Apoptosis and autophagy are increased because of up-regulated Gm5524 and down-regulated Gm15645. MALAT1 up-regulated increases albumin permeability and matrix metalloproteinases-2 (MMP-2) activity. LOC105374325 up-regulated increases apoptosis, as well as the expression of Bax and Bak. Mesangial cell: Up-regulated Arid2-IR promotes collagen I, α-SMA, and proliferation. Erbb4-IR up-regulated increases collagen I and collagen IV. Overexpression of PVT1 increases the amount of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), and FN1. Cell proliferation, P38, apoptosis signal-regulating kinase 1 (ASK1), FN, and α-SMA are promoted by NEAT1 up-regulating. Up-regulated ASncmtRNA-2 increases TGF-β1 and FN expression. Overexpressed Gm4419 increases monocyte chemoattractant protein-1 (MCP-1), IL-1β, TNF-a, FN, and collagen IV expression. Overexpression Hottip increases the amount of IL-6, TNF-a, collagen I, collagen IV, FN, and PAI-1. Up-regulated CAS2 increases the protein level of FN and collagen IV. Up-regulated NONHSAG053901 increases the amount of TGF-B, IL-1β, and IL-6. MCP-1, TNF-a, and cell proliferation are increased because of overexpressed Rpph1. Cell proliferation and cyclin D1 are increased by overexpressed H2k2. CDKN2B-AS1 up-regulated increases the expression of N-cadherin, collagen I, FN, and collagen IV. Overexpressed MEG3 increases TGF-β1, a-SMA, TNF-β, CRP, IL-1β, IL-6, and MCP-1. The down-regulation of CYP4B1-PS1-001 increases cell proliferation and collagen I, FN, PCNA, and cyclin D1 expression. Epithelial cell: HOXA11-AS up-regulated increases apoptosis, cellular injury, and the expression of MCP-1. Increased ENST00000453774.1 promotes cell autophagy along with the expression of FN and collagen I. H19 overexpressed increases FN, α-SMA, collagen I, and collagen IV expression, but decreases E-cadherin. Up-regulated MEG3 increases N-cadherin and vimentin expression, but decreases E-cadherin. Increased NEAT1 restrains apoptosis, but promotes the expression of α-SMA, vimentin, TGF-β1, and connective tissue growth factor (CTGF). HOTAIR overexpression promotes cleaved-caspase-3 expression. Down-regulated TSI increases the expression of snail 1, collagen I, and α-SMA. GAS5 up-regulation increases CTGF, collagen I, and FN1 expression. LINC00339 overexpression increases IL-1β, IL-18, TGF-β1, CTGF, α-SMA, and TIMP-1 expression. LINC00667 up-regulated enhances the level of FN, collagen IV, TGF-β1, CTGF, α-SMA, and TIMP-1. Tubulointerstitial injury, the expression of TGF-β1, FN, collagen I, α-SMA, and phosphorylation of Smad3 are promoted by Arid2-IR up-regulating. Up-regulated UC.173 promotes apoptosis. Increased LOC105375913 enhances the expression of snail, collagen I, and FN. Up-regulated CHCHD4P4 increases apoptosis and vimentin while decreases E-cadherin expression.