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. 2020 Aug 1;10(8):131. doi: 10.3390/life10080131

Figure 4.

Figure 4

LncRNAs in vascular damage and rarefaction. LncRNAs regulate cells involved in the physiological and pathogenic processes of kidney vessels and capillaries. Endothelial cells: The silencing of MALAT1 results in more migration, angiogenic sprout length, discontinued sprout length, and repress the proliferation as well as the expression of TNF-α, IL-6, and serum amyloid antigen 3 (SAA3). The increase of SENCR promotes migration and the ability to generate capillary. The knockdown of H19 decreases cell number and suppress the ability to generate capillary. Decreased Meg3 promotes p53 signaling and apoptosis, and inhibits proliferation. Down-regulation of GAS5 increase the proliferation, cell migration, and capillary formation. The loss of ANRIL prevents VEGF up-regulation. AK094457 knockdown enhanced cell viability. Vascular smooth muscle cells (VSMCs): GAS5 knockdown increases cell viability, migration, and down-regulated the expression of α-SMA and calponin. The knockdown of SENCR inhibits the contractile phenotype of VSMCs and up-regulate migration.