Table 2.
Toxin families identified for each cerianthid species.
| Toxin Family ID | Pfam Domain | Cebr | Isn | Pasb | Pasm |
|---|---|---|---|---|---|
| Neurotoxin (%) | - | 7.1 | 17.4 | 11.0 | 13.3 |
| 332-1 propeptide toxin | ShK | 0 | 0 | 1 | 0 |
| Cysteine-rich venom protein | CAP | 2 | 1 | 10 | 2 |
| ShK-domain | ShK | 6 | 10 | 3 | 8 |
| Three-finger toxin | / | 1 | 1 | 0 | 1 |
| Turripeptide | Kazal_1 | 3 | 0 | 5 | 2 |
| U-actitoxin-Avd9a | ShK | 0 | 0 | 0 | 1 |
| U33-theraphotoxin-Cg1b | / | 0 | 0 | 1 | 0 |
| Hemostatic and Hemorrhagic Toxin (%) | - | 37.3 | 30.4 | 41.2 | 33.3 |
| Beta-fibrinogenase mucrofibrase-3 | Trysin | 0 | 0 | 0 | 1 |
| Blarina Toxin | Trysin | 3 | 0 | 1 | 0 |
| C-type lectin lectoxin | Lectin_C | 6 | 2 | 3 | 1 |
| Coagualtion factor X | Trypin | 1 | 2 | 2 | 0 |
| Coagulation factor V | F5_F8_type_C | 2 | 1 | 6 | 3 |
| Coagulation factor X-activating enzyme heavy chain | Pep_M12B_propep/Reprolysin | 1 | 0 | 1 | 0 |
| Galactose-specific lectin | Lectin_C | 4 | 0 | 9 | 3 |
| Ryncolin | Fibrinogen_C | 8 | 3 | 8 | 6 |
| Snaclec | Lectin_C | 2 | 1 | 3 | 0 |
| Snake venom 5′-nucleotidase | 5_nucleotid_C | 1 | 0 | 1 | 0 |
| Snake venom serine proteinase | Trypsin | 0 | 0 | 0 | 1 |
| Snake venom VEGF | PDGF | 0 | 1 | 1 | 0 |
| Thrombin-like enzyme | Trypsin | 1 | 0 | 3 | 0 |
| Thyrostimulin | DAN | 1 | 0 | 0 | 0 |
| Veficolin-1 | Collagen | 14 | 2 | 9 | 5 |
| Venom peptide isomerase heavy chain | Trypsin | 2 | 0 | 1 | 0 |
| Venom prothrombin activator (F5/F8 type C) | F5_F8_type_C | 6 | 3 | 15 | 4 |
| Venom prothrombin activator (Trypsin) | Trypsin | 9 | 5 | 8 | 7 |
| Zinc metalloproteinase-disintegrin | Pep_M12B_propep/Reprolysin | 2 | 1 | 4 | 4 |
| Membrane-Active (%) | - | 3.6 | 0 | 4.4 | 5.7 |
| DELTA-thalatoxin-Avl2a | MAPF | 0 | 0 | 1 | 1 |
| Jellyfish Toxin | / | 1 | 0 | 2 | 1 |
| Millepora cytotoxin | DERM | 0 | 0 | 2 | 0 |
| Stonutoxin/Neoverrucotoxin | / | 5 | 0 | 2 | 2 |
| Waprin | WAP | 0 | 0 | 1 | 2 |
| Mixed function enzyme (%) | - | 20.7 | 21.7 | 12.6 | 16.2 |
| Acetylcholinesterase | COesterase | 5 | 2 | 3 | 3 |
| Gilatoxin | Trypsin | 0 | 1 | 0 | 0 |
| L-amino-acid oxidase | Amino_oxidase | 6 | 1 | 4 | 3 |
| Peroxiredoxin | AhpC-TSA | 0 | 0 | 1 | 1 |
| Phospholipase-A2/Conodpine | Phospholip_A2 | 5 | 6 | 2 | 5 |
| Phospholipase-B | Phospholip_B | 1 | 1 | 1 | 0 |
| Phospholipase-D | / | 4 | 0 | 1 | 0 |
| Putative endothelial lipase | Lipase | 5 | 1 | 3 | 2 |
| Putative lysosomal acid lipase/cholesteryl ester hydrolase | Abhydro_lipase/Abhydrolase_1 | 4 | 3 | 3 | 3 |
| Trehalase | Trehalase | 0 | 0 | 1 | 0 |
| Venom phosphodiesterase | Phosphodiest | 5 | 0 | 4 | 0 |
| Protease Inhibitor (%) | - | 2.4 | 4.3 | 2.7 | 2.9 |
| Kunitz-type serine protease inhibitor | Knuitz_BPTI | 3 | 3 | 4 | 1 |
| U-actitoxin-Avd3m | Knuitz_BPTI | 0 | 0 | 0 | 1 |
| U24-ctenitoxin-Pn1a | Thyroglobin_1 | 1 | 0 | 1 | 1 |
| Allergen and Innate Immunity (%) | - | 12.7 | 2.2 | 13.2 | 5.4 |
| CRISP/Allergen/PR-1 | CAP | 1 | 0 | 1 | 0 |
| Venom allergen | CAP | 14 | 2 | 12 | 3 |
| Venom phosphatase | His_Phos_2 | 1 | 1 | 1 | 0 |
| Venom protease | Trysin | 1 | 0 | 3 | 3 |
| Venom serine carboxypeptidase | Peptidase_S10 | 0 | 0 | 1 | 0 |
| Venom serine protease | Trysin | 6 | 1 | 6 | 3 |
| Techylectin-like | Fibrinogen_C | 1 | 0 | 0 | 1 |
| Auxiliary Protein (%) | - | 14.8 | 20.2 | 14.8 | 19.0 |
| Astacin-like metalloprotease toxin | Astacin | 6 | 5 | 8 | 9 |
| Cystatin | Cystatin | 0 | 0 | 0 | 1 |
| Glutaminyl-peptide cyclotransferase | Peptidase_M28 | 1 | 1 | 1 | 1 |
| Hyaluronidase | Glyco_hydro_56 | 4 | 0 | 0 | 0 |
| Nematocyst expressed protein | Astacin | 6 | 3 | 11 | 6 |
| Neprilysin | Peptidase_M13_N | 1 | 1 | 3 | 0 |
| Reticulocalbin | EF-hand_7 | 5 | 3 | 3 | 2 |
| Venom protein 302 | IGFBP | 2 | 1 | 1 | 1 |
| TOTAL | - | 169 | 69 | 182 | 105 |
| Unknown | - | 25 | 5 | 24 | 11 |