Table 1.
Regulation of PTEN and its downstream targets by miRs in gastric cancer (GC) cells.
| MiR | Molecular Signaling | Results | References |
|---|---|---|---|
| MiR-28 | PTEN/PI3K/Akt | Downregulation of PTEN Stimulation of PI3K/Akt Promoting invasion and proliferation |
[106] |
| MiR-21 | PTEN/Akt | Inhibition of PTEN Stimulation of Akt Enhancing Bcl-2/Bax ratio |
[107,108] |
| MiR-26a MiR-106b MiR-214 |
PTEN | Decreasing PTEN expression Poor prognosis Low survival |
[109,110,111] |
| MiR-21 | PTEN/TGF-β/EMT | Downregulation of PTEN Induction of TGF-1/EMT axis Enhancing E-cadherin levels Reducing N-cadherin and vimentin levels Increasing migration of cancer cells |
[112] |
| MiR-214 | PTEN | Downregulation of PTEN Reducing cell cycle arrest |
[113] |
| MiR-301a | PTEN/Wnt/β-catenin | Suppressing PTEN Activation of Wnt signaling Promoting metastasis |
[114] |