Table 2.

LncRNAs regulating PTEN in GC cells and their relationship with proliferation and invasion.

LncRNA	Signaling Network	Results	References
PCAT18	MiR-107/PTEN/PI3K/Akt	Downregulation of miR-107 by PCAT18 Stimulation of PTEN signaling Inhibition of PI3K/Akt Inducing tumor growth inhibition	[169]
TUBA4B	MiR-214/PTEN MiR-216a/b-PTEN	Downregulation of miR-214 and miR-216a/b Stimulation of PTEN Suppressing proliferation and migration	[170]
DGCR5	MiR-23b/PTEN	Inhibition of miR-23b Stimulation of PTEN Induction of apoptosis	[171]
LINC00470	PTEN	Reducing PTEN stability and directing it into degradation Enhancing proliferation and invasion	[172]
AFAP1-AS1	PTEN/Akt	Reducing PTEN expression Stimulation of Akt Downregulation of pro-apoptotic factors PARP1, capase-3 and caspase-9	[173]
HOTAIRM1	MiR-17-5p/PTEN	Inhibition of miR-17-5p expression via sponging Upregulation of PTEN Decreasing viability and proliferation	[174]
FER1L4	MiR-106a-5p/PTEN	Inhibition of miR-106a-5p Stimulation of PTEN Disrupting proliferation	[175]
HOTAIR	MiR-17-5p/PTEN	Upregulation of miR-17-5p by HOTAIR Inhibition of PTEN Enhancing chemoresistance	[167]
PCAT1	EZH2/PTEN	Increasing EZH2 expression Downregulation of PTEN Stimulation of cisplatin resistance	[176]