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Schematic representation of PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin pathways and their crosstalk elements. PI3K/Akt/mTOR (blue, left), ERK1/2-MAPK (magenta, middle) and Wnt/β-catenin (green, right). Crosstalk elements between two or more pathways are highlighted in yellow. Arrowheads imply positive interactions while bars indicate inhibitory signals. CDK5: cyclin-dependent kinase 5.
