Table 1.

Studies supporting the relevance of the PI3K/Akt/mTOR signaling pathway in OL development.

Experimental Approach	Myelin Thickness	Myelination Degree	Phosphorylation of Downstream Elements	Myelin Proteins Expression	Nº of Mature OLs	Nº of OPCs	OL Differentiation	References
Bace1−/−	-	Normal	-	-	Normal	Normal	Normal	[39]
Akt-DD 1	+	+	+	+	Normal	Normal	Enhanced	[42]
Rapamycin 2	-	-	-	-				[45]
Ptenfl/fl; Cnp1Cre/+ Ptenfl/fl; Plp1CreERT2/+	+	+			Normal	Normal		[43]
Ptenfl/fl; Olig2Cre/+	+	+	+		Normal	Normal	Normal	[44]
CNPCre/+; Raptorfl/fl	-	-	-	-	-	+	Delayed	[46]
CNPCre/+; Rictorfl/fl	Normal	Slightly -		-	Normal	-	Increased	[46]
CNPCre/+; Rptorfl/fl	-	-	-	-	Normal	Normal		[47]
CNPCre/+; Rictorfl/fl	-	Delayed myelination	Normal	Normal	Normal	Normal		[47]
CNPCre/+; Rptorfl/fl; Rictorfl/fl	-	-	-	-	-	+	Delayed	[47]
CNPCre/+; Tsc1fl/fl		-	+	-				[47]
Olig1Cre/+; Rheb1fl/fl	Normal	-	-	-	-	+	Impaired	[50]
NG2Cre/+; Tsc1fl/fl	+ (later is normal)	Enhanced remyelination		+	Normal	Normal	Normal	[48]
Plp1Cre/+; Tsc1fl/fl	- (later is normal)	Delayed remyelination			Normal	Normal		[48]

(-) indicates lower levels or numbers, (+) indicates higher levels or numbers. ¹ constitutively active Akt, ² mTOR inhibitor.