Table 2.

Studies supporting the relevance of the ERK1/2-MAPK signaling pathway in OL development.

Experimental Approach	Myelin Thickness	Myelination Degree/Start of Myelination	Phosphorylation of Downstream Elements	Myelin Proteins Expression	Cellular Proliferation	Nº of Mature OLs	Nº of OPCs	OL Differentiation	References
MbpCre/+; TrkBfl/fl	-	-/Delayed		-	+	Normal	+	Normal	[60]
CNPCre/+; Fgfr1/2fl/fl	-	-/Delayed	-	-	Normal	Normal	Normal	Normal	[58]
CNPCre/+; Erk1−/−; Erk2fl/fl	-	Normal/Normal		-		Normal	Normal	Normal	[53]
hGFAPCre/+; Erk2fl/fl NG2-Cre/+; Erk2fl/fl		Slightly -/Delayed			Normal	-	Normal	Delayed	[55]
CNPCre/+; MEK1DD+/− (1)	+	Normal/Enhanced remyelination	+	+	Normal	Normal	Normal	Normal	[53]
CNPCre/+; MEK1DD+/− (1) Olig1Cre/+; MEK1DD+/− (1)	+	+/Normal	+	+		Normal	+		[57]
Olig1Cre/+; Erk1−/−;Erk2fl/fl					-	-	-		[57]

(-) indicates lower levels or numbers, (+) indicates higher levels or numbers. ⁽¹⁾ constitutively active MEK1.