Table 3.

Studies supporting the relevance of the Wnt/β-catenin signaling pathway in OL development.

Experimental Approach	Myelination Degree	Myelin Proteins Expression	Cellular Proliferation	Nº of Mature OLs	Nº of Immature OLs (OPCs)	OL Differentiation	References
Olig2CreERT2/+; APCfl/fl	-	-	-	-	-	Impaired	[71]
Axin2−/−	Delayed remyelination		Normal	-	Normal	Delayed	[72]
Treatment with XAV939 1	+	+	Normal	+	-	Enhanced	[72]
GSK-3Β inhibitors	+	+	+	+	+	Normal	[66]
Olig2Cre/+; DA-Cat 2	-	PLP+ decreased		-	Normal	Delayed	[64]
CnpCre/+; DA-Cat	-	-	Normal	-	Normal	Delayed	[65]
Tcf4−/−	-	-		-		Delayed	[73,74]

(-) indicates lower levels or numbers, (+) indicates higher levels or numbers. ¹ XAV939 stabilizes Axin2, ² constitutively active β-Catenin.