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. 2020 Aug 17;21(16):5901. doi: 10.3390/ijms21165901

Figure 7.

Figure 7

Gene set enrichment analysis (GSEA) of transcriptional profiles in patient-derived organoids. GSEA analysis using hallmark gene sets from the molecular signature database for the transcriptional difference in patient-derived organoids. (A) Enrichment plots of genes in hallmark_Wnt_beta-catenin-signaling; (B) hallmark_E2F_targets; (C) hallmark_G2M_checkpoint; (D) hallmark_MYC targets_V1 and (E) hallmark_MYC targets_V2 gene sets showed significant enrichment in 2,4-DAQ-sensitive tumor-derived organoids (ID: 01, 02, 04) versus 2,4-DAQ-resistant tumor-derived organoids (ID: 03, 05, 06). Enrichment plot of genes in (F) hallmark_Wnt_beta-catenin-signaling gene sets showed significant enrichment in 2,4-DAQ-sensitive tumor-derived organoids versus 2,4-DAQ-sensitive nonneoplastic lesions-derived organoids. NES—normalized enrichment score; NOM-P—nominal p-value; FDR-q—false discovery rate q-value.