Table 2.
Dysregulated miRNAs in different brain regions of ASD patients.
Tissue | Samples (ASD/Control) | Up-Regulated miRNA | Down-Regulated miRNA | Reference |
---|---|---|---|---|
Cerebellar cortex (BA 9) | 56 (28/28) | let-7g-3p, miR-10a-5p, miR-18b-5p, miR-20b-5p, miR-21-3p, miR-23a-3p, miR-107, miR-129-2-3p, miR-130b-5p, miR-148a-3p, miR-155-5p, miR-218-2-3p, miR-221-3p, miR-223-3p, miR-335-3p, miR-363-3p, miR-424-3p, miR-424-5p, miR-425-3p, miR-449b-5p, miR-450b-5p, miR-484, miR-629-5p, miR-651-5p, miR-708-5p, miR-766-3p, miR-874-3p, miR-887-3p, miR-940, miR-1277-3p, miR-3938, miR-2277-5p | miR-204-3p, miR-491-5p, miR-619-5p, miR-3687, miR-5096 | [24] |
Frontal cortex (BA 10) | 24 (12/12) | miR-7-5p, miR-19a-3p, miR-19b-3p, miR-21-3p, miR-21-5p, miR-142-3p, miR-142-5p, miR-144-3p, miR-146a-5p, miR-155-5p, miR-219-5p, miR-338-5p, miR-379-5p, miR-451a, miR-494, miR-3168 | miR-34a-5p, miR-92b-3p, miR-211-5p, miR-3960 | [68] |
Temporal lobe | 11 (5/6) | miR-146a | [92] | |
Postmortem cerebellar tissue | 26 (13/13) | miR-106a, miR-106b, miR-140, miR-146b, miR-181d, miR-193b, miR-320a, miR-381, miR-432, miR-539, miR-550, miR-652 | miR-7, miR-15a, miR-15b, miR-21, miR-23a, miR-27a, miR-93, miR-95, miR-128, miR-129, miR-132, miR-148b, miR-212, miR-431, miR-484, miR-598 | [103] |
STS + PAC (BA 22/41/42) | 18 (10/8) | miR-664-3p, miR-4709-3p, miR-4753-5p | miR-1, miR-297, miR-4742-3p | [104] |