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. 2020 Aug 18;21(16):5922. doi: 10.3390/ijms21165922

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The abundance of mRNA expressed for G Protein-Coupled Receptor 18 and markers involved in adiponectin signalling, fatty acid metabolism and oxidative capacity in red gastrocnemius skeletal muscle obtained from rats fed a high fat diet for 9 weeks to induce obesity. The diet induced obese (DIO) control rats, the DIO O-1602 rats and the DIO O-1918 rats were treated via intraperitoneal injection for a further 6 weeks. mRNA expression was normalised to the average of housekeeping genes cyclophilin and βActin and grouped data is reported as mean (arbitrary units) ± SEM. Figure 1a The red gastrocnemius treatment groups compared to the white gastrocnemius group (* significance p < 0.05). Figure 1b–i The DIO control group is compared to either the DIO O-1602 group or the DIO O-1918 group. (a) G Protein-Coupled Receptor 18 (includes both DIO red and white gastrocnemius); (b) Adiponectin Receptor 1 (AdipoR1); (c) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1 (APPL1); (d) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 2 (APPL2); (e) Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α); (f) Forkhead box protein 01 (FOXO1); (g) Fatty Acid Translocase/Cluster of Differentiation 36 (FATCD/36); (h) beta-hydroxyacyl-CoA dehydrogenase (βHAD); (i) Pyruvate Dehydrogenase Kinase 4 (PDK4).

The abundance of mRNA expressed for G Protein-Coupled Receptor 18 and markers involved in adiponectin signalling, fatty acid metabolism and oxidative capacity in red gastrocnemius skeletal muscle obtained from rats fed a high fat diet for 9 weeks to induce obesity. The diet induced obese (DIO) control rats, the DIO O-1602 rats and the DIO O-1918 rats were treated via intraperitoneal injection for a further 6 weeks. mRNA expression was normalised to the average of housekeeping genes cyclophilin and βActin and grouped data is reported as mean (arbitrary units) ± SEM. Figure 1a The red gastrocnemius treatment groups compared to the white gastrocnemius group (* significance p < 0.05). Figure 1b–i The DIO control group is compared to either the DIO O-1602 group or the DIO O-1918 group. (a) G Protein-Coupled Receptor 18 (includes both DIO red and white gastrocnemius); (b) Adiponectin Receptor 1 (AdipoR1); (c) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1 (APPL1); (d) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 2 (APPL2); (e) Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α); (f) Forkhead box protein 01 (FOXO1); (g) Fatty Acid Translocase/Cluster of Differentiation 36 (FATCD/36); (h) beta-hydroxyacyl-CoA dehydrogenase (βHAD); (i) Pyruvate Dehydrogenase Kinase 4 (PDK4).