Figure 2.
The abundance of mRNA expressed for markers involved in adiponectin signalling, fatty acid metabolism and oxidative capacity in white gastrocnemius skeletal muscle obtained from rats fed a high fat diet for 9 weeks to induce obesity. The DIO control rats, DIO O-1602 rats and the DIO O-1918 rats were treated via intraperitoneal injection for a further 6 weeks. mRNA expression was normalised to the average of housekeeping genes cyclophilin and βActin and grouped data is reported as mean (arbitrary units) ± SEM. The DIO control group is compared to either the DIO O-1602 group (* significance p < 0.05) or the DIO O-1918 group (* significance p < 0.05). (a) Adiponectin Receptor 1 (AdipoR1); (b) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1 (APPL1); (c) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 2 (APPL2); (d) Forkhead box protein 01 (FOXO1); (e) Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α); (f) beta-hydroxyacyl-CoA dehydrogenase (βHAD); (g) Fatty Acid Translocase/Cluster of Differentiation 36 (FATCD/36); (h) Pyruvate Dehydrogenase Kinase 4 (PDK4).