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. 2020 Aug 18;21(16):5922. doi: 10.3390/ijms21165922

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The abundance of mRNA expressed for markers involved in adiponectin signalling, fatty acid oxidation and oxidative capacity in C₂C₁₂ myotubes treated for 24 h with O-1918 (100 nM). mRNA expression was normalised to housekeeping gene Hypoxanthine Phosphoribosyltransferase (HPRT1) and grouped data is reported as mean (arbitrary units) ± SEM (* significance p < 0.05). (a) Nuclear Factor of Activated T-Cells calcineurin dependent 1 (NFATc1); (b) Peroxisome proliferator-activated receptor gamma co activator 1-alpha (PGC1α); (c) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1 (APPL1); (d) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 2 (APPL2); (e) Adenosine Monophosphate Kinase alpha 2 (AMPKα2); (f) Pyruvate Dehydrogenase Kinase 4 (PDK4).

The abundance of mRNA expressed for markers involved in adiponectin signalling, fatty acid oxidation and oxidative capacity in C₂C₁₂ myotubes treated for 24 h with O-1918 (100 nM). mRNA expression was normalised to housekeeping gene Hypoxanthine Phosphoribosyltransferase (HPRT1) and grouped data is reported as mean (arbitrary units) ± SEM (* significance p < 0.05). (a) Nuclear Factor of Activated T-Cells calcineurin dependent 1 (NFATc1); (b) Peroxisome proliferator-activated receptor gamma co activator 1-alpha (PGC1α); (c) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1 (APPL1); (d) Adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 2 (APPL2); (e) Adenosine Monophosphate Kinase alpha 2 (AMPKα2); (f) Pyruvate Dehydrogenase Kinase 4 (PDK4).