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. 2020 Aug 18;21(16):5925. doi: 10.3390/ijms21165925

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TAM subsets in primary colorectal tumors as visualized by multiplex immunofluorescence. (A) Image of M0 (CD68⁺iNOS⁻CD163⁻), M1 (CD68⁺iNOS⁺CD163⁻), M2 (CD68⁺iNOS⁻CD163⁺) and M3 (CD68⁺iNOS⁺CD163⁺) TAMs. (B) Representative images of colorectal tumors with high numbers of stromal TAMs (sTAMs) and intraepithelial TAMs (ieTAMs) (white: DAPI; red: cytokeratin⁺ tumor epithelium; blue: CD68⁺ TAMs). The white arrows indicate examples of TAMs with indicated phenotypes (A) or localizations (B). Abbreviations: CRC (colorectal cancer), iNOS (inducible nitric oxide synthase), ieTAM (intraepithelial TAM), sTAM (stromal TAM), TAM (tumor-associated macrophage).