Table 1.
Clinicopathological characteristics of patients with CRC and healthy donors in the study. Statistically significant p-values (≤0.05) are indicated in bold. Abbreviations: CRC (colorectal cancer), PBMC (peripheral blood mononuclear cells), TNM (tumor, node, metastasis).
| CRC Patients | Healthy Serum Donors | Healthy PBMC Donors | |||
|---|---|---|---|---|---|
| (N = 78) | (N = 40) | p-Value | (N = 10) | p-Value | |
| Age * | 0.392 | 0.028 | |||
| Mean (years) | 65.9 | 63.8 | 48.8 | ||
| Range (years) | 25–85 | 26–82 | 22–78 | ||
| Sex | 0.597 | 0.951 | |||
| Female | 35 (44.9%) | 20 (50.0%) | 5 (50.0%) | ||
| Male | 34 (55.1%) | 20 (50.0%) | 5 (50.0%) | ||
| Tumor location | |||||
| Colon | 64 (82.1%) | ||||
| Rectum | 14 (17.9%) | ||||
| TNM classification | |||||
| Stage 0 | 4 (5.1%) | ||||
| Stage I | 12 (15.4%) | ||||
| Stage II | 26 (33.3%) | ||||
| Stage III | 26 (33.3%) | ||||
| Stage IV | 10 (12.8%) | ||||
| Tumor differentiation | |||||
| Well/moderate | 62 (79.5%) | ||||
| Poor | 13 (16.7%) | ||||
| Unknown | 3 (3.8%) | ||||
| Tumor-positive lymph nodes | |||||
| No | 45 (57.7%) | ||||
| Yes | 32 (41.0%) | ||||
| Unknown | 1 (1.3%) | ||||
| Neoadjuvant radiotherapy | |||||
| No | 69 (88.5%) | ||||
| Yes | 9 (11.5%) | ||||
| Adjuvant chemotherapy | |||||
| No | 49 (62.8%) | ||||
| Yes | 29 (37.2%) | ||||
* Age at time of surgery was used for patients and time of serum/PBMC donation for healthy donors.