Table 2.
Univariate and multivariate analyses of sCD163 serum levels for the DFS of CRC patients. Univariate and multivariate analyses for DFS were generated for stage 0–III CRC patients (N = 58). The median sCD163 level (2.0 mg/L) was used as a cutoff. Statistically significant p-values (≤0.05) are indicated in bold. Abbreviations: CI (confidence interval), CRC (colorectal cancer), DFS (disease-free survival), HR (hazard ratio), sCD163 (soluble CD163), TNM (tumor, node, metastasis).
| Univariate Analysis for DFS | Multivariate Analysis * for DFS | |||||
|---|---|---|---|---|---|---|
| Parameter | HR | 95% CI | p-Value | HR | 95% CI | p-Value |
| Age (continuous) | 1.0 | 1.0–1.1 | 0.340 | |||
| Age | ||||||
| ≤70 years | 1.0 | |||||
| >70 years | 2.0 | 0.9–4.3 | 0.072 | |||
| Sex | ||||||
| Female | 1.0 | |||||
| Male | 1.4 | 0.7–3.1 | 0.358 | |||
| TNM classification | ||||||
| Stage 0/I | 1.0 | |||||
| Stage II | 2.0 | 0.5–7.6 | 0.299 | |||
| Stage III | 5.9 | 1.7–20.4 | 0.005 | |||
| Tumor location | ||||||
| Colon | 1.0 | |||||
| Rectum | 1.9 | 0.8–4.5 | 0.117 | |||
| Tumor differentiation grade | ||||||
| Well/moderate | 1.0 | |||||
| Poor | 0.9 | 0.3–2.5 | 0.775 | |||
| sCD163 (continuous) | 1.1 | 0.8–1.6 | 0.446 | 1.0 | 0.7–1.4 | 0.903 |
| sCD163 | ||||||
| Below-median | 1.0 | 1.0 | ||||
| Above-median | 3.1 | 1.4–7.1 | 0.007 | 2.4 | 1.0–5.7 | 0.049 |
* Corrected for age (categorized as ≤70 or >70 years age) and TNM classification.